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In my February, 2004 newsletter, I mentioned a clinical pilot study carried out by Dr. R. K. Marwaha et al at the Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Entitled "Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study.", the study was performed between
February 2000 and May 2003. Sixteen out of 38 (42%) blood transfusion dependent thalassemics fulfilled the trial criteria for final analysis. To summarise the findings during period of Dr Wheatgrass juice ingestion:
It is interesting to note that twenty of the original trial participants were withdrawn due to "indiscipline in intake and an insufficient duration of intake of wheat grass juice." This does not surprise me considering they were asked to consume 100mls per day. Many find fresh wheatgrass juice unpalatable, as I do. Some of these children were as young as four and, unless they really enjoyed the taste, would have found it very difficult to comply with the regime. They would I believe, have found it much easier to ingest a dilute solution of my extract. I contacted Dr. Marwaha, mentioning the extract and wheatgrass website. At the time it did not seem likely he would want to repeat or extend the pilot study using the extract, so I did not suggest it. Nonetheless, because of the substantial clinical experience I have had using Dr Wheatgrass as a therapeutic agent and the extensive scientific literature available on the topic, I felt quite certain that it would work just as well as fresh Dr Wheatgrass juice. More importantly, the extract is infinitely more palatable and the dose required would amount to no more than 1 to 3 mls. a day. Also, wheatgrass cultivation is unnecessary as the extract's potency lasts for years, if not indefinitely. The next development was totally unexpected. The Murdoch Children's Research Institute at the Royal Children's Hospital in Melbourne (Australia) is involved in a number of research projects, one of which is thalassemia. This unit, the Cell & Gene Therapy Research Group is headed by Professor Panos Ioannou who has spent a large part of his working life researching thalassemia. Also, because of his work in the production of artificial chromosomes, he made a significant contribution to the Human Genome Project. On 3rd May he requested a sample of wheatgrass extract saying, "We have recently developed very specific assays for the induction of foetal haemoglobin, ("The assay is based on detecting production of HbF in human erythroleukaemia cells using a fluorescent protein gene that is used to replace the genes for HbF") to facilitate the discovery of pharmacological agents that might be therapeutic for thalassaemia. Given the reported effects of Dr Wheatgrass juice on thalassaemia, (Dr. Marwaha's pilot study) we would very much like to test Dr Wheatgrass juice (extract) whether it can cause a significant increase in foetal haemoglobin." This point is important. Fetal hemoglobin, (HbF) which has a substantially higher affinity for oxygen than adult hemoglobin, develops in the fetus during the last six months of gestation. As both mother and fetus share the same blood supply, fetal hemoglobin essentially draws off oxygen from the mother's blood. This enables the fetus to survive in the uterus. After birth, fetal hemoglobin levels fall rapidly and in the adult represents less than two percent of total hemoglobin in the body. It has been found that stimulation or induction of fetal hemoglobin in thalassemia can improve the patient's clinical condition. Although drugs exist that have this function, e.g. hydroxyurea, they lack specificity and may have a variety of serious side effects. Professor Ioannou assayed the Dr Wheatgrass extract for fetal hemoglobin induction on three separate human cell clones. On 14 July he reported that over a 5 day period: "Our measurements suggest a 3-5 fold increase in the production of HbF by the wheat grass extract. This is a substantial increase and could certainly provide an explanation why some thalassaemia patients may derive significant benefit." Of course, these laboratory results may or may not bear a relationship to what one could expect in the thalassemic patient. However, given the quite significant reduction in transfusion requirements noted in some of the patients in Dr. Marwaha's pilot study, Professor Ioannou's findings strongly suggest they could have resulted from induction of fetal hemoglobin by Dr Wheatgrass. I think it is worth noting again that the Murdoch Institute results were achieved using a wheatgrass extract that contained virtually no chlorophyll. This fact further supports my belief that chlorophyll, like hemoglobin, has a specific function to perform in nature. As hemoglobin transports oxygen within the red blood cell, so does chlorophyll assist photosynthesis within the chloroplast. Nothing more, nothing less. In conclusion, I believe the two new studies relating to wheatgrass and induction of fetal hemoglobin mentioned here give more than a glimmer of hope to thalassemic patients. Commercial wheatgrass products such as fresh juice, tablets, powders and nutritional supplements are cheap, readily available and virtually devoid of adverse effects. While more studies are clearly necessary, thalassemics may have nothing to lose and possibly much to gain from ingesting wheatgrass, in one form or another, daily. While it is not possible from the current studies to predict the optimal dose of wheatgrass extract for a beneficial effect on thalassaemia, I recommend that in order to benefit fully from the biological activity of the herb, thalassemics, like anyone taking wheatgrass, need to hold it in the mouth for at least a minute before swallowing. References:
Dr Wheatgrass - food for thought as well as for a healthy body. Instead of "chlorophyll", it is probably better to think "Growth Factor Activators". The Dr Wheatgrass Dream Is Well And Truly Alive And Its Users Are Well! Dr Wheatgrass Products Now?Now You Can Easily >> Detox With Zeolite, Rid Your Body Of Toxins Now >> Discover The Magic Of Our Amazing Himalayan Salt >> Enjoy Better Breathing With A Himalayan Salt Inhaler >> Enjoy The Natural Benefits Of Dr Wheatgrass Products >> Alkalyze Your Body With A Portable Alkaline Water Ionizer Stick >> Light Up Your Life With A Natural Shaped Himalayan Rock Salt Lamp >> Discover The Magic Of Pure Clean Fluoride Free Water And What It Can Do For You >> Improve The Quality Of Your Air, Water And Food With A Cold Corona Ozone Generator Disclaimer: It is important to mention that none of the products presented are a medicine and are not being promoted by us as such. Any information is for educational purposes only and is not intended to diagnose any illness. In any case of illness it is highly recommended to contact a qualified medical practitioner.Stay Healthy and Be Happy Naturally |